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Through her work, Professor Cenci Nilsson has developed preclinical models mimicking the symptoms of Parkinson’s disease and L-DOPA-induced dyskinesia, exploiting these models to discover disease mechanisms and new therapeutic approaches. With this motivation, MultiPark’s coordinator was awarded the 2022 Bengt Falck Prize in Neuroscience. In this extensive interview, Angela Cenci Nilsson shares he

https://www.multipark.lu.se/article/multiparks-coordinator-awarded-bengt-falck-prize-neuroscience - 2025-10-31

Imaging methods are valuable tools for understanding neurodegenerative diseases and monitoring the therapeutic effects of new treatments. That is why MultiPark researchers with expertise in clinical imaging gather across research groups. Clinical imaging methods is a new special interest group (SIG) addressing scientific and technological needs to apply these methods in research. Nicola Spotorno t

https://www.multipark.lu.se/article/clinical-imaging-methods-special-interest-group - 2025-10-31

People with Parkinson´s disease (PD) often develop abnormal involuntary movements (dyskinesias) during the course of their treatment with dopaminomimetic drugs.  In this new collaborative project, Angela Cenci Nilsson (Lund), Mattias Rickhag (Copenhagen) and Gilad Silberberg (Stockholm) will unravel the connections between dyskinesia and changes in the way the cerebral cortex and the striatum proc

https://www.multipark.lu.se/article/new-collaborative-project-tackles-previously-unknown-mechanisms-parkinsons-dyskinesias - 2025-10-31

Martino Avallone spent the past four years developing tools for mapping gene expression and proteins in the brain to investigate basic biological questions and to elucidate the molecular mysteries contributing to Parkinson’s disease. On 29 September, he defends his thesis work done in the Molecular Neuromodulation research group. Here, he explains the impact these tools will hopefully have in scie

https://www.multipark.lu.se/article/genetic-tools-studying-parkinsons-disease-phd-interview-martino-avallone - 2025-10-31

Megg Garcia-Ryde’s thesis sheds light on the early pathological processes in Alzheimer’s disease and the interplay between neurons and microglia as the disease evolves. October 10, she defends her thesis. Now, she gives her perspectives from a close collaboration between two of MultiPark’s experimental research groups and how she brings together the expertise of both groups. Tell us about your res

https://www.multipark.lu.se/article/neuroimmune-crosstalk-early-alzheimers-disease-phd-interview-megg-garcia-ryde - 2025-10-31

In today's scientific world, microscopic images have become a powerful resource for research. With access to advanced microscopes, researchers can now create unique images of structures and objects. Beautiful and captivating images that can also convey complex context to a wider audience. Microscopic images offer a clear advantage over purely quantitative measurements: they allow us to see the str

https://www.multipark.lu.se/article/making-invisible-visible-magic-microscopic-images - 2025-10-31

Is it possible that a single biomarker can detect all types of diseases related to dopamine deficiency in the brain? Yes, that's what a research group in Lund is discovering. "We have observed that an enzyme in cerebrospinal fluid and in blood is a useful marker for identifying all types of Parkinson's-related diseases with high accuracy," says Oskar Hansson, who led the study. The marker in quest

https://www.multipark.lu.se/article/new-blood-marker-can-identify-parkinsonian-diseases - 2025-10-31

Jana Rájová’s research turns light on gene expression in different parts of the brain affected by Parkinson’s disease. October 23, she defends her thesis in the Molecular Neuromodulation research group. In this interview, she tells about how it has been to combine wet and dry lab work and about the technical advances in the field. Tell us about your research! “Throughout my Ph.D. journey, my resea

https://www.multipark.lu.se/article/gene-expression-parkinsons-disease-phd-interview-jana-rajova - 2025-10-31

A recent publication by MultiPark researchers at Lund University’s Lund Stem Cell Center gives a closer look at the making of a novel stem cell therapy for Parkinson’s Disease, STEM-PD, which has been approved for a Phase I/IIa clinical trial in Europe. Parkinson's Disease is a neurodegenerative disorder that affects almost 8 million people worldwide, causing movement difficulties due to the loss

https://www.multipark.lu.se/article/closer-look-making-novel-stem-cell-therapy-parkinsons-disease - 2025-10-31

Sweden has made significant strategic investments into the national infrastructure MAX IV, with world-unique instruments usable across disciplines. One emerging area is within medical sciences. MultiPark researchers now gather across research groups to facilitate the usage of these state-of-the-art techniques available just around the corner. MAXIV for high-resolution, sub-cellular X-ray measureme

https://www.multipark.lu.se/article/maxiv-high-resolution-sub-cellular-x-ray-measurements-special-interest-group - 2025-10-31

The human brain is an incredibly intricate organ that regulates everything from our motor skills to our memories. But how did it evolve into the complex structure we see today? Researchers at Lund University offer new insights in their latest study, published in Science Advances, detailing how a specific group of genetic elements have influenced the development of the human brain over time. Hidden

https://www.multipark.lu.se/article/how-mobile-dna-shapes-human-brain - 2025-10-31

Andreas Bruzelius, a Ph.D. student at Lund University, defended his PhD thesis on Friday, 20 October 2023. Andreas' research focuses on generating brain cells, specifically interneurons, in the lab, which has significant implications for the study of neurodegenerative and neuropsychiatric disorders. Combining cell biology and electrophysiology, his work has the potential to create personalized dis

https://www.multipark.lu.se/article/generating-gabaergic-interneurons-phd-interview-andreas-bruzelius - 2025-10-31

Understanding the very first pathological events at the molecular level is key to developing treatments preventing neurodegenerative diseases. With a novel microspectroscopy approach combining optical and photothermal imaging, MultiPark researchers can follow early alterations of proteins involved in Alzheimer’s disease, before neurons degenerate. Their discoveries are published in the Journal of

https://www.multipark.lu.se/article/new-imaging-approach-visualizes-early-structural-changes-amyloids-living-brain-tissue-0 - 2025-10-31

Every year, the patient organization Parkinson Skåne organizes a half-day of themed lectures on Parkinson's disease. The strategic research area, MultiPark, usually sponsors the moderator costs and contributes with research talks. In addition, the researchers arrange four times a year the well-attended popular science seminar evenings MultiPark café for members of the patient organization. This co

https://www.multipark.lu.se/article/extended-cooperation-between-multipark-and-patient-organization-parkinson-skane - 2025-10-31

January 2024 is the start of a new electoral term for MultiPark’s management. While Angela Cenci Nilsson will remain the coordinator, Oskar Hansson will be replaced for the next three years. The vice coordinator's mission will be shared between a health scientist and a clinician. Maria H. Nilsson and Per Odin explain how they will contribute to leading MultiPark. According to MultiPark’s steering

https://www.multipark.lu.se/article/double-multipark-gets-two-new-vice-coordinators - 2025-10-31

Intensive efforts are being made in medical research to discover the genomic causes of undiagnosed hereditary diseases. Persistent work and new technology are providing answers to several previously unsolved, enigmatic neurological disorders. Spinocerebellar ataxia type 4 was one of these, but now a research team in Lund, Sweden, have identified the gene that is responsible. Almost half a million

https://www.multipark.lu.se/article/researchers-have-found-genetic-cause-type-hereditary-ataxia-sca4-long-unresolved-conundrum - 2025-10-31

To stimulate the international recruitment of excellent young researchers, Lund University has launched a call for positions as associate senior lecturers (biträdande universitetslektor) reserved for candidates with postdoctoral research experience in institutes outside of Sweden (and not having held a position of scholarship in Sweden after February 15, 2020). The candidates should be academicall

https://www.multipark.lu.se/article/lund-university-launches-international-recruitment-programme-young-researchers - 2025-10-31

Researchers have succeeded in restoring lost brain function in mouse models of stroke using small molecules that in the future could potentially be developed into a stroke therapy. “Communication between nerve cells in large parts of the brain changes after a stroke and we show that it can be partially restored with the treatment", says Tadeusz Wieloch, senior professor at Lund University who led

https://www.multipark.lu.se/article/new-study-lost-brain-function-restored-after-stroke - 2025-10-31

MultiPark researchers have discovered a new promising pharmacological approach stimulating recovery after stroke. Professor Tadeusz Wieloch tells about how the MultiPark Innovation Office supported the first steps in converting their academic research findings into something with commercial potential that may finally benefit the patients. Around 80% of people who suffer a stroke permanently lose s

https://www.multipark.lu.se/article/turning-academic-discoveries-therapies-how-multipark-innovation-office-helps - 2025-10-31

Raquel Garza Gómez is a Ph.D. student at Lund University, who will be defending her thesis on January 19, 2024. With a background in computational biology, Raquel's research focuses on studying the role of transposable elements in the human brain. Transposable elements refer to DNA sequences capable of moving from one part of the genome to another. Her research aims to provide a better understandi

https://www.multipark.lu.se/article/transposable-elements-healthy-and-diseased-human-brain-phd-interview-raquel-garza-gomez - 2025-10-31